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Cold Spring Harbor Perspectives In Biology

  0 Downloads   |   2 Pages 341 Words   |   Published Date: 17/02/2017

Question:

Doiscuss about the patient who was asymptomatic right after the spleenectomy?

 

Answer:

Discussion

In the case discussed, the patient was asymptomatic right after the spleenectomy. After few weeks, symptoms of sepsis appeared. Spleenectomy was important in this case because injuries sustained after the accident depended on the spleenectomy (Kristinsson, 2013).

1st Discussion Post

The wound sustained after the spleenectomy was the origin of the septic, which led to the flared up discomfort and health issues. The wound became the breeding ground for infectious microorganisms.

Replication in Prokaryotes and Eukaryotes is different. RNA primers in prokaryotes are longer than RNA primers in eukaryotes, some additional proteins are present during eukaryotic replication, eukaryotes have multiple replication origins, regulation of and there is another difference between the telomeres. The ends of the DNA are known as telomeres, replicating them is the problem. While the leading strand can be copied easily, the lagging strand is not easy to copy. In case of eukaryotes there is an overhang which cannot be avoided. Another problem is that after every round of cell division the DNA is shortened. The length of telomeres is different in Prokaryotes and eukaryotes. Eukaryotes also have a distinct process for replicating telomeres.

2nd Discussion Post

Telomeres are an integral part of replication. But the role of telomere is different in prokaryotes and eukaryotes. The lengths are small and replication procedure is different (Strzyz, 2016).

Homologous recombination is a process in which similar nucleotide chains or sequences are exchanged between identical DNA molecules (Jasin & Rothstein, 2013).

3rd Discussion Post

The proteins for homologues recombination in prokaryotes are different from the proteins for homologous recombination in eukaryotes.

 

References

Jasin, M., & Rothstein, R. (2013). Repair of strand breaks by homologous recombination. Cold Spring Harbor perspectives in biology, 5(11), a012740.

Kristinsson, S. Y., Gridley, G., Hoover, R. N., Check, D., & Landgren, O. (2013). Long-term risks after splenectomy among 8,149 cancer-free US veterans: a cohort study with up to 27 years follow-up. Haematologica, haematol-2013.

Strzyz, P. (2016). DNA replication: Rif1 times replication. Nature Reviews Molecular Cell Biology.

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